Dr. Amy Paller, who has spent 30 years researching the disorder, for the first time has found the reason the disease causes the red skin and has a promising biologic drug to begin testing soon in clinical trials.
In a new study published in the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman-Yassky of Mount Sinai Medical School, discovered that an arm of the immune system – the Th17 pathway – in these patients is way too active, and the higher its activity, the worse the disease severity.
Paller is about to launch a clinical trial to test a new biologic (a cutting-edge drug) for it, with the goal of targeting and calming down this pathway.
More information is available on Northwestern University website.
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